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2014年12月25日 イイね!

Cell Snapshot accelerate antibiotic test to inhibit bacteria proliferation

Researchers have developed a test based on imaging to quickly and accurately determine the bacterial sensitivity to antibiotics. This method can reduce the testing time from about 16 hours to four hours, it can effectively help doctors treat patients more quickly, as well as curb a variety of resistance caused by excessive use of antibiotics and misuse of antibiotics - which has been upgraded and become a global health problem. When the bacteria proliferated in the case of antibiotics, they will be considered have the ability to resist drugs , however it will takes 16-20 hours to detect the bacteria growth .

To accelerate this process, Jungil Choi and his colleagues designed a test called single-cell morphological analysis (SCMA), it can track the growth of individual bacterial cells. A camera is capable to capture the delayed imaging of cells on chips , while the delayed imaging is caused by an antibiotic shapes changes , researchers can analyze the shape pattern in images to determine the cell growth.

Importantly, the test will take cell swelling and filaments formation into consideration, they are part of the normal cellular response, but it often is mistaken for cell growth. The researchers used a wide range of anti-microbial agents to test four kinds of standard bacterial strains and almost 200 hospital samples , including the notorious methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Compared with the clinical gold standard, SCMA gave the same accurate result within 3-4 hours. The researchers plan to next year to turned over SCMA test to the Korea Food and Drug Safety Department approval.

If want to get more details info about the following research performance , please pay your attention to Bioabb official website http://www.bioabb.com/categories/Antibody/Monoclonal-Antibody . As a world famous biotechnology company , Bioabb has established the comprehensive platform for the development of research antibodies , diagnostic antibodies and others antibodies . Concentrate on antibodies development , Bioabb has developed more than 5000 antibodies , covering disease detection , biology research , health care & life science development , Bioabb representative monoclonal Antibody - Mouse Anti-Flag Tag monoclonal antibody has approved international quality certificate , highly praised by clients around the world !
Posted at 2014/12/25 11:38:01 | コメント(0) | トラックバック(0) | 日記
2014年11月20日 イイね!

Researchers identify key mechanism for blocking leukemia

Researchers have identified two types of key proteins which play an important role in acute myeloid leukemia progression and recurrence . They also show that by targeting these proteins it can block the development of leukemia. This study is done in an animal model, may provide great resistance to develop effective chemotherapy to against leukemia .

The researchers said that even existing chemotherapy drugs can easily get rid of mature cancer cells , many patients still relapse, this problem has troubled scientists for a long time. Because of most patients’ bone marrow have residual leukemic stem cells which will defend this therapy , lead to recurrence. Previously carcinogenic two proteins mutations has been determined , the patients with gene mutations is usually suffer from poor prognosis , but the scientists have been unclear what mechanisms cause stem cells with mutations evolve into leukemia.

In Cell Reports magazine, the researchers describe mechanisms leading to the development of acute myeloid leukemia, identified two proteins FAK and PAK1 is a key factor. In mice experiment , the researchers found, eliminate or "passed out" to the gene which can generate FAK and PAK1 can inhibit the development of leukemia in mice, even though the bone marrow stem cells contain oncogenic protein mutation . Elimination of FAK and PAK1 protein does not prevent the mice to produce and maintain normal blood system.

By using several mice and human cells and tissue samples , the researchers identified several compounds drugs can be targeted FAK and PAK1 (now carry out experimental studies, but has not been approved for use in humans) . For the details research info , please visit here http://www.bioabb.com/products/Chloramphenicol-%28CAP%29-ELISA-kit.html . Bioabb is a professional elisa kit manufacturer as well as supplier , they provide cost-effective Chloramphenicol (CAP) ELISA kit for detection of Chloramphenicol . No significant cross-reactivity or interference was observed in this process . Bioabb is a worth relying on Chloramphenicol (CAP) ELISA kit supplier , visit more product info , welcome to Bioabb now !
Posted at 2014/11/20 17:41:24 | コメント(0) | トラックバック(0) | 日記
2014年11月20日 イイね!

Researchers identify key mechanism for blocking leukemia

Researchers have identified two types of key proteins which play an important role in acute myeloid leukemia progression and recurrence . They also show that by targeting these proteins it can block the development of leukemia. This study is done in an animal model, may provide great resistance to develop effective chemotherapy to against leukemia .

The researchers said that even existing chemotherapy drugs can easily get rid of mature cancer cells , many patients still relapse, this problem has troubled scientists for a long time. Because of most patients’ bone marrow have residual leukemic stem cells which will defend this therapy , lead to recurrence. Previously carcinogenic two proteins mutations has been determined , the patients with gene mutations is usually suffer from poor prognosis , but the scientists have been unclear what mechanisms cause stem cells with mutations evolve into leukemia.

In Cell Reports magazine, the researchers describe mechanisms leading to the development of acute myeloid leukemia, identified two proteins FAK and PAK1 is a key factor. In mice experiment , the researchers found, eliminate or "passed out" to the gene which can generate FAK and PAK1 can inhibit the development of leukemia in mice, even though the bone marrow stem cells contain oncogenic protein mutation . Elimination of FAK and PAK1 protein does not prevent the mice to produce and maintain normal blood system.

By using several mice and human cells and tissue samples , the researchers identified several compounds drugs can be targeted FAK and PAK1 (now carry out experimental studies, but has not been approved for use in humans) . For the details research info , please visit here http://www.bioabb.com/products/Chloramphenicol-%28CAP%29-ELISA-kit.html . Bioabb is a professional elisa kit manufacturer as well as supplier , they provide cost-effective Chloramphenicol (CAP) ELISA kit for detection of Chloramphenicol . No significant cross-reactivity or interference was observed in this process . Bioabb is a worth relying on Chloramphenicol (CAP) ELISA kit supplier , visit more product info , welcome to Bioabb now !
Posted at 2014/11/20 17:40:32 | コメント(0) | トラックバック(0) | 日記
2014年11月14日 イイね!

Scientists draw out nerve cells key gene mapping

Ear capsule (otocyst) located at the side of the body, containing the progenitor cells of most mature cell types in mature inner ear , previously , the scientists had found that different progenitor cells crowd in early otocyst can be divided into dispersed axis area by developmental lineage analysis as well as gene expression research .
According to the latest research , researchers deeply analyzed the 382 individuals cells of the neural cell lines as well as the otocyst in development , completed a high contrast quality RT-PCR detection , analyzing 96 representative ear marker genes , transcripts related signaling pathways, as well as new ear-specific gene to construct single-cell resolution listen follicle cells of mice , and the reconstruction figure of neuroblastoma cells .

In this latest study, researchers from the developing ear capsule, and 382 individual cells into neural cell lines in-depth analysis, completed high contrast quality of RT-PCR detection, analysis of 96 representative ear tag has been built gene transcripts associated signaling pathways, as well as new ear-specific gene construct single-cell resolution, and early follicle cells of mice listen to reconstruct Figure neural cell lines.

By multivariate cluster analysis , principal component analysis and neural network data analysis , the scientists deeply distinguish nerve layered cells , and they also describe the gene expression phase state .Additionally , the researchers also constructed a three-dimensional model ear capsule, detailing description of the precise spatial expression area of each individual cell . These findings not only put a new bioinformatics models, but also reveals the neuroblasts development in the early stage and different signal pathways dynamic mechanism in prosensory domain specific process .

If you want to get more details info about this research ,you can visit here http://www.bioabb.com/products/Human-glucocorticoid%28GC%29ELISA-Kit.html . Bioabb specialized in good quality elisa kit production and custom service . Their represent elisa kit -Human Cortisone ELISA Kit is deeply praised by the clients from all over the world due to its high sensitivity , good efficiency as well as low cost. Bioabb has accumulated large amount of elisa kit manufacturing experience , their mature technical route can make sure the high quality and utilization of their Human Cortisone ELISA Kit. If you want to buy cost-effective Human Cortisone ELISA Kit , welcome to Bioabb now .
Posted at 2014/11/14 17:24:33 | コメント(0) | トラックバック(0) | 日記
2014年11月13日 イイね!

Bacterial "communication system" can be used to block or kill cancer cells

Cancer, although always is dangerous, but the real threat to life is that when the cancer began to spread to different areas and throughout the body. Now, University of Missouri (MU) researchers found that a molecule used as a communication system by bacteria can be manipulated to prevent the spread of cancer cells. MU Veterinary Medical comparative oncology and epigenetics laboratory assistant research professor and deputy director Senthil Kumar said .The communication system can be used to "tell" the cancer cells how to act, even the command of death.

"During the infection, the bacteria will release molecules, enabling them to communicate with each other ," Kumar said, who led the study. " the signal according to the types of the molecules to tell other bacteria to evade the immune system or even stop the spread. The researchers also found that , if they introduced the 'stop spreading' bacterial molecules into cancer cells , then these cells not only will stop proliferation, but they also will begin to die. "

The researchers believed that bacteria communication molecule called ODDHSL can be used for the treatment human pancreatic cancer cells. After treatment, the human pancreatic cancer cells will stop breeding, failed to migrate and begin to die.

"The reason why we can use the pancreatic cancer cells because these cells are the most powerful as well as most aggressive and difficult to kill cancer cells in human bod . This method of treatment showed that the it is promising to applied to like a series of aggressive disease such as pancreatic cancer. And they also believe it may also be used for other types of cancer cells treatment . For more details info , click here http://www.bioabb.com/products/Rabbit-anti%252dGuinea-Pig-IgG-polyclonal-Antibody%2CBiotin-conjugated.html . Bioabb specialized in high quality monoclonal antibody production and custom service . Experienced years development , Bioabb now has become a world famous biotechnology company , succeed in producing thousands of monoclonal antibodies . Bioabb is a reliable monoclonal antibody supplier . Bioabb offers thousands of monoclonal antibodies for your choice , such as Rabbit anti-Guinea Pig IgG polyclonal Antibody,Biotin conjugated , Mouse anti- abscisic acid monoclonal antibody and many others animal species , for more details antibody info , welcome to Bioabb website !
Posted at 2014/11/13 17:46:11 | コメント(0) | トラックバック(0) | 日記

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Advantages and limitations of monoclonal antibodies  
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2014/10/13 18:17:25
Monoclonal antibodies therapeutic development trends 
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2014/07/17 14:13:48
Scientists successfully isolate the protein that can control brain activity 
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2014/06/26 17:11:22

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