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Department of Pathology, Beijing Tiantan Hospital, Beijing Institute ofDepartment of Neurosurgery, Xu Li Sun Shuqing recently found in clinicaland basic research of brain tumor, glioma tissue P170, MGMT, TOP II and GST- by 4 kinds of proteins associated with resistance to chemotherapy,chemotherapy, prognosis between their expression in gliomas of glioma patients close. This study will help develop individual treatment, improve the clinical effect of chemotherapy. According to project leader Li Guilin Professor introduction, P170 is theexpression of multidrug resistance genes and proteins, the concentration of a variety of anticancer drugs on the cell could reduce. MGMT is a DNArepair human serum albumin, can lead to tumor cell resistance to alkylating drugs, itsenzyme content is higher, the stronger the resistance. TOP II is a nuclear matrix protein, can be used as an important index to judge the prognosis ofglioma grading. Glutathione S transferase is one of the important factors of multi drug resistance, the glutathione S transferase PI (GST- PI) play a major role.

The researchers chose Tiantan Hospital Department of Neurosurgery half a year to complete the 108 glioma patients underwent operation, were detected in the 4 index. The study found, the expression of P170 protein ingrade IV gliomas, significantly higher than the expression in grade II ~ III grade of glioma. To observe the effect of chemotherapy in patients with part of postoperative found, vincristine, flower base drugs on the expression of P170 protein in patients with poor effect. The protein expression of MGMTnegative patients survival than patients with positive expression of long,negative patients sensitive to alkylating drugs. There are 74.3% high expression in varied degrees of resistance to alkylating drugs, only 25.7% of the patients with low expression is sensitive to alkylating agents, the prognosis is good.

The study also found that, the expression of TOP protein in the cell cyclewere higher, the degree of differentiation of glioma cells, the lower level, the expression of the protein is higher. High expression of the survival of the patients than in patients with low expression of short survival. GST- ; no expression in glioma tissue in 11.1% patients, these patients sensitive to chemotherapy and radiotherapy, the prognosis is good. GST- expression by tumor tissue of patients with 88.9%, on the part of patients undergoing chemotherapy in the choice of nimustine hydrochloride and other drugs should be carefully.Protein has become more and more important for us . And it has been widely used in our daily life . If you want to build a health life and the strong body , protein can give great help for you.Lacking of protein may have bad influence on human body ,click here to see the details info about protein benefits http://www.cusabio.com/pro_18.html
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First aid kits are a collection of various contents used for first aid in case of an emergency. The contents of fist aid kit vary from region to region, and the purpose it is designed for. Besides the normal use, many first aid kits in these days contain the survival tools. Hence it is also known as survival kit.First aid kits consist of emergency medicines, bandages, antiseptic lotions, bandages and topical medications like antiseptic ointments, tincture, antibacterial and antifungal creams, burn gels etc. Other than the common things listed above, there are certain contents available with some first aid kits. They are listed as follows along with their uses.

Pocket mask: Pocket mask is otherwise known as CPR mask. It is very useful for delivering rescue breaths particularly in cases of cardiac arrest. These masks have built-in oxygen intake tubes and provide 60% of oxygen to patient when somebody exhales through the one-way filter valve. These can provide sufficient air to the patient to live up even from the exhaled air of the provider.Face shield: Face shields are designed to protect the face from chemical or environmental hazards. There are certain standards for designing these shields in various countries.

The modern and advanced first aid kits contain many other life saving tools. These include:Ambu bag: Ambu bag is a big valve mask which is used to provide pressure ventilation in case of inadequate breathing.Oropharyngeal airway: the oropharyngeal airway (OPA) is used for unconscious patients as these stimulate the patient's gag reflex. It is necessary to choose the correct size of OPA against the patient's head and then insert into the patient's mouth upside down. It can be rotated 180 degrees after getting the contact with the back of the throat. Certain precautions should be taken while doing this. The device is removed carefully without rotating it.

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