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2014年10月30日 イイね!

Chitosan polyester material contribute to repairing the fracture nerve

According to the recently news, scientists have created substance mixed by nature and man-made material ,which can be used to repair broken nerves. In the apparel industry, the soft natural fiber such as mixed polyester and cotton can make products maintaining good breathability as well as not easy to wrinkle. In a recent study, scientists prepared crab shell material and industrial polyester to make mixed fibers .

According to experts , manufacturing of nerve guide tube is very strict. It must be biocompatible, maintaining stable structure in solution, in addition , it also need to effectively maintain the shape while maintaining flexibility, only to satisfy these situations , can the guide tube be stitched to the nerve.Although manufacturing nerve guide tube is very difficult, but it does not mean can not be achieved. Modern medicine extracted structural proteins from an animal cell - collagen can be used to produce small pipes and channels, supporting the nerve repair. But collagen is more expensive, but also may cause adverse immune response and exclusion.

So scientists are focus on the crab. Chitosan is a substance which exists in biological shell , which is very east to obtain and is also very cheap . Chitosan is biocompatible, does not trigger an immune response. In the researches , scientists fused chitosan and polycaprolactone , the latter is a common used polyester with biocompatibility . After the combination of the two , it generate a new nano-level materials , which is similar to the natural tissue surrounding human cells act as the role of connection. Compared with another biological material - polylactic acid - glycolic acid copolymer , chitosan - polyester fiber material is the most stable at present .

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Posted at 2014/10/30 18:35:30 | コメント(0) | トラックバック(0) | 日記
2014年10月30日 イイね!

"MARCKS" protein can cause a chemical reaction called phosphorylation

Alzheimer's disease is the most common type of dementia, the latest research conducted by Tokyo Medical and Dental University, and they showed that before the onset of Alzheimer's , proteins in brain nerve cells become abnormal , according to this mechanism, it is expected to develop new treatments to treat this disease in the future. So far , studies have found that β-amyloid in the brain of the patients with Alzheimer's appeared abnormal accumulation , which is the key factor to lead to brain cell damages .

Tokyo Medical and Dental University researchers said that they operate by gene, breeding experimental mice which will suffer Alzheimer's , then they analyzed the proteins play an active role in brain tissue before the onset of the experimental mice , finally finding that the among the 17 kinds of proteins, there is a protein known as "MARCKS" play an active role before the appearance of β-amyloid protein , the amount of this protein is significantly higher compared to normal mice.

Research Group survey found that, "MARCKS" protein can cause a chemical reaction called phosphorylation, leading to synaptic abnormalities. Synaptic is a combination of the Ministry of neurons, responsible for delivering a variety of visual and auditory information. The team leader Gangze both said: "This result will help for early diagnosis of Alzheimer's disease and the development of therapeutic drugs. The researchers concluded that protein “MARCKS”will induce chemical reaction called phosphorylation , leading to synaptic abnormalities , while the synaptic is a combination of the Ministry of neurons, responsible for delivering a variety of visual and auditory information . This new discovery will contribute to early diagnosis of Alzheimer's disease and the development of therapeutic drugs. "

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Posted at 2014/10/30 18:33:51 | コメント(0) | トラックバック(0) | 日記

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Advantages and limitations of monoclonal antibodies  
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Monoclonal antibodies therapeutic development trends 
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