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Recently, researchers from the University of California, San Diego School of Medicine, School of Medicine, found that a protein which is essential for regulation of cell cycle progression actually activate a key tumor suppressor factor , rather than eliminating tumor suppressor factor in precious studies .

The research result was published in the journal eLife. Cyclin D was consider as a progress which can help driving complex multi-stage process in the first stage of the synthesis of cell replication (cell cycle) ,including the interactions with retinoblastoma (Rb) protein , the main function of Rb is to prevent cells over growth by inhibiting the progress of cells cycle, until cells are preparing division , RB is a tumor suppressor protein.

But Rb mutation or dysfunction is associated with several major cancers , which are considered as promoting cancer development as well as Cyclin D , because Cyclin D is believed to eliminate tumor suppressor function by phosphorylation . The Researchers Dr. Steven F. Dowdy and his colleagues carefully calculated the amount of phosphate added to the RB in cell cycle progression , which up to 14 , but the scientist found that Cyclin D only add one single phosphate , which play an important role in activating RB , rather than inactivated it. Researchers concluded that this discovery fundamentally changed the understanding for origin of molecules related to cancers and G1 phase of the cell cycle regulation .

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Non-destructive technique for detecting the non-radioactive glucose molecules intake degree in tumor can help diagnose types of cancers and evaluate the patient treatment effects , which is the latest research performance published in "Nature Medicine".  

Compared with normal tissue, tumors need to consume more glucose to produce energy and manufacturing cell proliferation required blockers. The new technology developed by Simon Walker-Samuel calls glucoCEST  , which has high sensitivity in measuring the in-taking of glucose metabolism in tumor , comparing with others gold standard technique and others technologies , such as tumor metabolic labeling . And they have confirmed various types of colorectal cancer which have different fatal structure through this technology .

Due to the technology has been proven with same effect as well as others radioactive detection technology , and the technology uses unlabeled glucose, which will reduce the cost the clinical application, making it become easier to use. The researchers believe that this new technology can also be used to identify variation within the tumor cells, thus affecting drug reactions during treatment, but also for smaller tumor assessment.

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Although the therapy has been greatly improved, but for two adult suffered from acute myeloid leukemia (AML) , there was only one person will survive from it . For 65 years or older, acute myeloid leukemia average survival period of less than one years; but researchers speculate that the incidence of leukemia stem cells may be due, in patients with leukemia stem cells in the body and can not be completely cleared, these leukemic stem cells in patients with relapse is the ultimate cause of death.

Researchers come from Goethe-Universitat Frankfurt am Main researched the drawbacks of acute myeloid leukemia stem cells ,finding a lipoxygenase calls 5-LO , which play an key role in leukemia stem cell survival .Previous studies have found a 5-LO role in inflammatory diseases such as asthma pathogenesis, the researchers Jessica Roos professor said the study, we found that acute myeloid leukemia subgroup of leukemic stem cells might be 5- LO inhibitors effectively selectively attacks, but the phenomenon can be observed in a cell culture model and mouse models of leukemia.

=The researchers said the study provide new research evidence and clues for acute myeloid leukemia treatment . At the latter part of the study , the researchers also revealed the the functions and mechanism of 5-lipoxygenase inhibitors in leukemia stem cell . For more details info you can visit http://www.bioabb.com/categories/Protein/Native-Protein/ . Bioabb is a world famous biotechnology company, engaged in high quality biology products production and technical service .

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Guangmei Zhongshan Medical Research team found that natural virus M1 can selectively infect and destruction a variety of in - vitro cancer cells without any side effects , including liver cancer, colorectal cancer, bladder cancer, melanoma (melanoma) and son on . According to latest research data , global cancer (cancer) incidence rate rapid growth, current treatments is far away from the increasing clinical demands . Yan Guangmei research group found that, M1 virus is a separation virus comes from China's Hainan Island, which can selectively infect and kill a variety of in vitro cancer cells , including liver cancer, colorectal cancer, bladder cancer, melanoma (melanoma), and it has no side effects on normal cells.

Whole animal experiments showed that the intravenous injection of M1 virus can significantly enriched in tumor tissue and inhibit tumor growth, normal organs are not affected. In addition to the cellular level and animal experiments, the research group also uses clinical biopsy specimens in vitro culture model further confirmed the validity and specificity of the new oncolytic virus .It is reported that the research will contribute to elucidate new natural oncolytic viruses selectively kill tumor cells M1 mechanisms and the development of new targeted anticancer drugs . Bioabb is a world famous biotechnology company , focus on high quality antibody production .

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