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With China aging issues have become increasingly prominent, neurodegenerative diseases closely related to age, such as Parkinson's disease (Parkinson's Disease, PD), Alzheimer's disease (Alzheimer's Disease, AD) and other diseased population also tends to go up, becoming a major problem affecting the quality of life of older persons. Studies have shown that Parkinson's syndrome is associated with brain dopaminergic globus pallidus missing

Globus pallidus is a key nuclear group to adjust the movement loop , mainly involved in inhibiting involuntary movement, the lacking of dopamine in the globus pallidus leads to the inhibition deletion, resulting in tremors and other symptoms. Deep brain stimulation can be seen as an important means of treatment of Parkinson's disease, the globus pallidus is its electrodes buried targets, which makes the study on development and regulation of the globus pallidus become particularly important.

By studying the gene knockout mice of the original cadherin family members , along with a series of molecular biology and neurobiology research experiments , clarifying the important function of the original cadherin genes during development in the globus pallidus , providing a theoretical basis for Parkinson's syndrome and others neurodegenerative diseases .

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US researchers at Vanderbilt University announced a new surgical robot which is still under the development . The robot can precisely locate from cheek to brain area , from cheek to brain can avoid significant brain and nervous system area. If you are suffering from severe epilepsy, patients without any effective methods to treat this disease can use this robot to conduct a less invasive treatment . Traditional methods sometimes necessary to drill into the hot site of epilepsy skull damage . But this method has certain risk , it is often used only as a last resort. While this robot enter into the brain with a more precise routes, nor is straight forward, but in accordance with tortuous road , which can minimize the extent of the brain damage. The graduate David Comber said that the Needles) feeling very flexible , who is the person in charge of the designing of this robot .

The reason for using flexible design, is to allow the robot can force the heated nitinol needle through the pipeline, so that the needle can fit the shape of the pathway , making it walking in pipeline which is t5hroughout the brain .When the needle left the end of the pipe gradually , the needle will be able to regain its original shape. Comber said the advancing needle looks like a caterpillar.

During surgery , doctors will use NMR to scan and track the subtle process when the needle through the soft tissue . While the needle enter into brain , it can not cut surrounding brain tissue , and it is very difficult to ensure this . Comber said: "The tip through the place, part of the tip will follow to go." Any errors are likely to be devastating. Currently machine reports accuracy is 1.18 mm . And they predicted that robot will be applied into surgery within10 years .

Maybe this research surprised you , but it may come true in nearly future , which may promote the modern medicine research and development , help against a series of difficult disease . This new invention also contribute a new round of science development . For more details info , you can visit http://www.bioabb.com/pages/Immunology-Experiment-Service.html . Bioabb offers excellent immunology technical experiment service to serve biology and modern medicine research . Bioabb experienced years development and now it has become a world famous biotechnology company , engaged in high quality and excellent immunology technical experiment service supplying . Besides best competitive price , Bioabb also provides you with perfect after sale service .

Researchers from Harvard Medical School, Beth Israel Deaconess Medical Center (Beth Israel Deaconess Medical Center, BIDMC) through a series of experiments and found that the critical role of α- acetylated proteins of the N terminal for cell survival , providing important information to deeply understand apoptosis

N- terminal acetylation is a widespread modified form in eukaryotes, of which the N-alpha-Acetylation is usually occur simultaneously in translation ,generally occurs when the nascent peptide chain has about 40 residues. This modified form is common, such as 80% soluble protein in bacterial cells are the N-terminal α- acetylation

Precious studies have shown that N-terminalα- acetylated protein is closed related to sensitivity of cells to apoptotic signals . In this research , by biochemical experiment , the researchers analyzed the protein acetylation status , confirming that protein N-terminal α- acetylated is controlled by acetyl-CoA , , which is the activate form of Acety l, ivolved in various acetylation reaction as well as important intermediate products in carbohydrates, fats, amino acid oxidase .

The researchers also suggested that due to Bcl-xL is a well-known anti-apoptotic protein which affects mitochondrial metabolism, therefore they think that this factor may build a bridge between the protein and apoptosis , which confirming that N-terminalα- acetylated proteins can promote cell survival . For more details info , please visit here . Bioabb is a world famous biotechnology company , specialized in cost-effective proteins production and custom service . Bioabb offers thousands of native and recombinant proteins http://www.bioabb.com/products/Bovine-milk-%CE%B2%252dLactoglobulin.html to meet various demands for biology and life science research , if you are in need of high quality native protein and recombinant proteins , Bioabb is the best choice for you !

Recently, researchers from Tulane University Cancer Center, said, the commonly used prostate cancer therapy may have a bigger harm on the patient's than the benefits . And the related research performance published in the International Journal of Onco Targets Ther. Patients diagnosed with prostate cancer in men are using androgen deprivation therapy (ADT) over decades, namely the drugs injection which can suppress testosterone production . The latest research indicated that this castration therapy probably does not increase the survival benefit in patients with prostate cancer, it instead lead to other health problems in patients.

Researchers Oliver Sartorsaid patients are potential candidates for ADT therapy , suppression of testosterone will increase the cure rate of specific malignant cancer radiation , so it is a standard therapy for patients with metastatic cancer, in past years, doctors have been using ADT therapy to treat early prostate cancer. Now researchers have found that ADT therapy may be more harmful than they were .

The researchers found that ADT therapy could potentially cause health problems, including hot flashes, lack of libido, muscle weakness, fatigue, diabetes risk, each year in the United States there are 240,000 men are diagnosed with prostate cancer, of which more than half of the patients are early cancer and low risk of death of individuals . Now that you have known that ADT therapy is not safe for prostate cancer treatment . Now a new prostate cancer therapy is urgent need to be developed . So monoclonal antibody therapy is developed .

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Researchers have invented method to produce a light-sensitive membrane protein,which is capable to manipulate neural activity in test tube . This latest research performance was published in “Nature - Methodology ” .By using the light-sensitive protein and the corresponding light stimulation , neuronal activity can be controlled. To meet the demands of gene research and gene therapy , the scientists are always try their best to design a novel light-sensitive protein which have a better neuron controlling ability .

Ernst Bamberg as well as his colleagues developed a protein engineering strategy , integrate the gene of two kinds of light-sensitive microbial protein to produce hybrid protein . This method make sure the colocalization and equal expression of the proteins in cells , so as to exactly activate or inhibit specific neuronal , which also contribute to studying brain functions and behavior.

The engineered protein developed by Bamberg and his colleagues can respond to a wider range of the spectrum. The light-sensitive protein developed by Ernst Bamberg can use "white" light to activate nerve cells, at the same time it is possible to apply to the ongoing gene therapy to restore vision. However, researchers also need to test this mutant protein on model animal .

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