Using an aging biomarkers called clock epigenetic clock, researchers from the University of California, Los Angeles (University Of California Los Angeles), etc for the first time they found that obesity may accelerate the aging of human liver ,and their related research published in the International the journal PNAS, the study may help explain the pathogenesis of age-related diseases, such as liver cancer and other diseases.
Although scientists have speculated obesity makes human aging more quickly, but there is no valid evidence to prove; but in this paper the researchers found that overweight can negatively affect the human organism selectively organization; researcher Professor Horvath said this study, we evaluated the impact of obesity on the body's biological age of a variety of tissues, and the aging of the body's clock can use a time-keeping mechanism to accurately calculate the human body organs, tissues and various cell types of the age, the researchers mainly concerns a method called methylation biochemical processes of the body, the methylated DNA molecule is to be chemically modified in the process.
For this study, researchers analyzed more than 1200 copies of human tissue samples, including 140 copies of the liver tissue samples in order to study the association of epigenetic clock acceleration and weight; when obesity can affect fat, muscle or blood apparent when the genetic age, researchers have found that body mass index (BMI) for each additional 10, epigenetic liver age will increase 3.3 years. For example, a 5.5 ft, weighing 140 pounds female BMI was 23.3, while the other one and the same height and weight of her female 200 pounds BMI of 33.3, the latter than the former, the liver of female aging female liver 3 years. The researchers said that for some people is concerned, due to obesity leads to accelerated aging performance of the very obvious, and some can even reach 10 years.
The rapid reduction of body weight caused by the treatment does not reverse the aging process, at least not in the short term. The researchers will continue to post further studies are needed to determine whether obesity was inhibited liver tissue premature aging individuals can reduce the risk of diabetes and liver cancer, the researchers plan to develop a new model to study the molecular mechanism . For more details info , please visit here
http://www.bioabb.com/categories/Small-Molecule/Peptide/.
Posted at 2014/11/12 13:59:41 | |
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