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Recently, a study published in the journal PNAS reveals the increased gene expression in fatal skin cancer melanoma may enhance the death risk of tumors , which is also a new potential therapeutic target. The researchers stressed that this is the first confirmed PHIP (PH domain interacting protein) play a role in cancer. Director of the Melanoma Research and Treatment Center Sutter Pacific Medical Foundation, MD, Mohammed Kashani-Sabet CPMCRI scientist who led the study.

We have shown that this gene is the proliferation of melanoma increased risk of death as well as a marker. Studies of this gene helps us understand malignant melanoma. Hope that further research will lead to have targeted treatment of melanoma and other cancers. To determine the effect of high levels of protein PHIP melanoma metastasis, the researchers tested the mice and patients with melanoma tissues of the protein. The researchers found that increased expression of survival PHIP reduce the human and mouse related. Subsequently inhibit murine melanoma PHIP found mice survived significantly longer than mice PHIP expression. The researchers also studied 345 patients with melanoma tissue by PHIP low expression levels found in patients with longer survival than patients with high levels of PHIP.

We learned that in mice and humans, the expression of tumor PHIP more higher risk of cancer spread, the shorter survival. In order to understand what kind of melanoma may carry PHIP expression, the team studied the genetic makeup of tumors. Recent studies have focused on other genes in melanoma, particularly in BRAF. Of which about 50% of melanoma patients had mutations in the gene. The US Food and Drug Administration approved the mutated BRAF inhibitors, in 2011, when can prolong survival in patients with metastatic melanoma. However, there is no regulation of melanoma metastasis to the mutant gene is still unknown, which means that there is no mutation in BRAF, effective treatment of patients, only a small number of melanoma.

The researchers found that, in the absence of BRAF mutations in melanoma under high PHIP level. The researchers hope that the future of personal melanoma treatment of patients with other cancers and can target such as PHIP, promoting gene transfer carried out. For more details info , please click here RABBIT C-PEPTIDE ELISA KIT .

With China aging issues have become increasingly prominent, neurodegenerative diseases closely related to age, such as Parkinson's disease (Parkinson's Disease, PD), Alzheimer's disease (Alzheimer's Disease, AD) and other diseased population also tends to go up, becoming a major problem affecting the quality of life of older persons. Studies have shown that Parkinson's syndrome is associated with brain dopaminergic globus pallidus missing

Globus pallidus is a key nuclear group to adjust the movement loop , mainly involved in inhibiting involuntary movement, the lacking of dopamine in the globus pallidus leads to the inhibition deletion, resulting in tremors and other symptoms. Deep brain stimulation can be seen as an important means of treatment of Parkinson's disease, the globus pallidus is its electrodes buried targets, which makes the study on development and regulation of the globus pallidus become particularly important.

By studying the gene knockout mice of the original cadherin family members , along with a series of molecular biology and neurobiology research experiments , clarifying the important function of the original cadherin genes during development in the globus pallidus , providing a theoretical basis for Parkinson's syndrome and others neurodegenerative diseases .

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US researchers at Vanderbilt University announced a new surgical robot which is still under the development . The robot can precisely locate from cheek to brain area , from cheek to brain can avoid significant brain and nervous system area. If you are suffering from severe epilepsy, patients without any effective methods to treat this disease can use this robot to conduct a less invasive treatment . Traditional methods sometimes necessary to drill into the hot site of epilepsy skull damage . But this method has certain risk , it is often used only as a last resort. While this robot enter into the brain with a more precise routes, nor is straight forward, but in accordance with tortuous road , which can minimize the extent of the brain damage. The graduate David Comber said that the Needles) feeling very flexible , who is the person in charge of the designing of this robot .

The reason for using flexible design, is to allow the robot can force the heated nitinol needle through the pipeline, so that the needle can fit the shape of the pathway , making it walking in pipeline which is t5hroughout the brain .When the needle left the end of the pipe gradually , the needle will be able to regain its original shape. Comber said the advancing needle looks like a caterpillar.

During surgery , doctors will use NMR to scan and track the subtle process when the needle through the soft tissue . While the needle enter into brain , it can not cut surrounding brain tissue , and it is very difficult to ensure this . Comber said: "The tip through the place, part of the tip will follow to go." Any errors are likely to be devastating. Currently machine reports accuracy is 1.18 mm . And they predicted that robot will be applied into surgery within10 years .

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Researchers from Harvard Medical School, Beth Israel Deaconess Medical Center (Beth Israel Deaconess Medical Center, BIDMC) through a series of experiments and found that the critical role of α- acetylated proteins of the N terminal for cell survival , providing important information to deeply understand apoptosis

N- terminal acetylation is a widespread modified form in eukaryotes, of which the N-alpha-Acetylation is usually occur simultaneously in translation ,generally occurs when the nascent peptide chain has about 40 residues. This modified form is common, such as 80% soluble protein in bacterial cells are the N-terminal α- acetylation

Precious studies have shown that N-terminalα- acetylated protein is closed related to sensitivity of cells to apoptotic signals . In this research , by biochemical experiment , the researchers analyzed the protein acetylation status , confirming that protein N-terminal α- acetylated is controlled by acetyl-CoA , , which is the activate form of Acety l, ivolved in various acetylation reaction as well as important intermediate products in carbohydrates, fats, amino acid oxidase .

The researchers also suggested that due to Bcl-xL is a well-known anti-apoptotic protein which affects mitochondrial metabolism, therefore they think that this factor may build a bridge between the protein and apoptosis , which confirming that N-terminalα- acetylated proteins can promote cell survival . For more details info , please visit here . Bioabb is a world famous biotechnology company , specialized in cost-effective proteins production and custom service . Bioabb offers thousands of native and recombinant proteins http://www.bioabb.com/products/Bovine-milk-%CE%B2%252dLactoglobulin.html to meet various demands for biology and life science research , if you are in need of high quality native protein and recombinant proteins , Bioabb is the best choice for you !

Recently, researchers from Tulane University Cancer Center, said, the commonly used prostate cancer therapy may have a bigger harm on the patient's than the benefits . And the related research performance published in the International Journal of Onco Targets Ther. Patients diagnosed with prostate cancer in men are using androgen deprivation therapy (ADT) over decades, namely the drugs injection which can suppress testosterone production . The latest research indicated that this castration therapy probably does not increase the survival benefit in patients with prostate cancer, it instead lead to other health problems in patients.

Researchers Oliver Sartorsaid patients are potential candidates for ADT therapy , suppression of testosterone will increase the cure rate of specific malignant cancer radiation , so it is a standard therapy for patients with metastatic cancer, in past years, doctors have been using ADT therapy to treat early prostate cancer. Now researchers have found that ADT therapy may be more harmful than they were .

The researchers found that ADT therapy could potentially cause health problems, including hot flashes, lack of libido, muscle weakness, fatigue, diabetes risk, each year in the United States there are 240,000 men are diagnosed with prostate cancer, of which more than half of the patients are early cancer and low risk of death of individuals . Now that you have known that ADT therapy is not safe for prostate cancer treatment . Now a new prostate cancer therapy is urgent need to be developed . So monoclonal antibody therapy is developed .

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