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Myosin myosins are a class of molecular motors in eukaryotic cells, playing an important role in cell movement and transport , such as myosin II plays an important role in muscle contraction and cell division process; myosin protein VIIa (MYO7A) in cells in the body is responsible for the transport of molecules, it is particularly important for the function of the hair cells of human hearing and eye development; myosin X can help to establish a connection between the neurons in development and others neurons

Researchers from Hong Kong University of Science and Technology have discovered a myosin X is different from the past cognition, antiparallel coiled - curled dimer structure, the researchers believed that this dimerization may be able to helpmyosin X walking in a single and multi-beam actin filaments. The study found the movement of unconventional myosin in actin filaments usually needs protein dimer . While about myosin dimer, a widely accepted mechanism is that it expand towards to motor lever arm domains through the terminal carboxyl group of amino acid residues , forming a parallel coiled - Curl dimer.

The researchers found that myosin X predicts to appear a curl - in the area of curl , it forms a high stable and antiparallel coiled -anti-CC . If by a single point mutation, or with a parallel coiled coil having a similar length to replace anti-CC , it will interrupt the anti-CC. And in further experiments, the researchers found that anti-CC as well as the single α-helical domain of myosin X can connect each other by semi-rigid screw connector . All of the research results suggested that dimerization directed by anti-CC may help contribute to the myosin X walking on single and multi-beam actin filaments

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Recently, researchers from abroad study found that for many of the body's immune cells , to resist infection requires a cell survival protein A1 to make cell developed and maintain its normal function. This finding will provides a new clue to help us to get a better understand of leukemia, allergies and autoimmune diseases . And the researchers found If there is no protein Al , lymphocytes and granulocytes can not develop or can not have an effect on the infection.

Protein A1 is a member of Bcl-2 protein family, which can control cell survival. The researchers removed protein A1from immune cells , and then they studied the function and their growing state after the lacking of protein A1. The researcher , Dr Herold suggested that , over past decades , we have known proteins that are essential for cell survival , such as protein Bcl-2 , which is vital for immune cells growth and functions . Due to the protein A1 and other proteins do not normally play a cooperative role , so that the researchers all ignored this kind of protein . At present , the works of the researchers reveals that the protein A1 plays a series of important role in the normal functioning of the immune system .

The researchers said the study provides great assistance for us to get a better understanding of many human diseases , such as leukemia, autoimmune diseases , these disease are usually caused by dysfunction of immune cells . This research reveals that protein A1 is essential for normal immune cells functions . And at the same time the researchers also provide us with a series of advanced research method . This research will provides a new target to treat these disease such as leukemia, allergies and autoimmune diseases .

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According to the recently news, scientists have created substance mixed by nature and man-made material ,which can be used to repair broken nerves. In the apparel industry, the soft natural fiber such as mixed polyester and cotton can make products maintaining good breathability as well as not easy to wrinkle. In a recent study, scientists prepared crab shell material and industrial polyester to make mixed fibers .

According to experts , manufacturing of nerve guide tube is very strict. It must be biocompatible, maintaining stable structure in solution, in addition , it also need to effectively maintain the shape while maintaining flexibility, only to satisfy these situations , can the guide tube be stitched to the nerve.Although manufacturing nerve guide tube is very difficult, but it does not mean can not be achieved. Modern medicine extracted structural proteins from an animal cell - collagen can be used to produce small pipes and channels, supporting the nerve repair. But collagen is more expensive, but also may cause adverse immune response and exclusion.

So scientists are focus on the crab. Chitosan is a substance which exists in biological shell , which is very east to obtain and is also very cheap . Chitosan is biocompatible, does not trigger an immune response. In the researches , scientists fused chitosan and polycaprolactone , the latter is a common used polyester with biocompatibility . After the combination of the two , it generate a new nano-level materials , which is similar to the natural tissue surrounding human cells act as the role of connection. Compared with another biological material - polylactic acid - glycolic acid copolymer , chitosan - polyester fiber material is the most stable at present .

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Alzheimer's disease is the most common type of dementia, the latest research conducted by Tokyo Medical and Dental University, and they showed that before the onset of Alzheimer's , proteins in brain nerve cells become abnormal , according to this mechanism, it is expected to develop new treatments to treat this disease in the future. So far , studies have found that β-amyloid in the brain of the patients with Alzheimer's appeared abnormal accumulation , which is the key factor to lead to brain cell damages .

Tokyo Medical and Dental University researchers said that they operate by gene, breeding experimental mice which will suffer Alzheimer's , then they analyzed the proteins play an active role in brain tissue before the onset of the experimental mice , finally finding that the among the 17 kinds of proteins, there is a protein known as "MARCKS" play an active role before the appearance of β-amyloid protein , the amount of this protein is significantly higher compared to normal mice.

Research Group survey found that, "MARCKS" protein can cause a chemical reaction called phosphorylation, leading to synaptic abnormalities. Synaptic is a combination of the Ministry of neurons, responsible for delivering a variety of visual and auditory information. The team leader Gangze both said: "This result will help for early diagnosis of Alzheimer's disease and the development of therapeutic drugs. The researchers concluded that protein “MARCKS”will induce chemical reaction called phosphorylation , leading to synaptic abnormalities , while the synaptic is a combination of the Ministry of neurons, responsible for delivering a variety of visual and auditory information . This new discovery will contribute to early diagnosis of Alzheimer's disease and the development of therapeutic drugs. "

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Researchers from the Fred Hutchinson Cancer Center in Seattle, USA, etc. through studies , showing that patients receiving chest radiation therapy to treat Wilms tumor may enhance the risk of breast cancer due to the exposure to radiation . Related research results were published in international magazine《cancer》. This research reveals cancer screening guidelines should perhaps be re-evaluated in order to promote the early diagnosis of Wilms tumor patients and prompt risk of breast cancer

Wilms' tumor is a rare childhood kidney cancer, which can spread to the lungs, when the cancer spreads, patients need 12-14 gray degree radiation therapy; In order to clarify whether the radiation exposure may affect the risk of suffering from breast cancer, researchers Norman Breslow and colleagues conducted research on 2500 young women in their childhood with wilms tumor radiotherapy . In the surviving female patients who received chest radiation , more than 20% of individuals suffering from breast cancer at the age of 40 , while the patients with wilms tumor who didn’t receive radiotherapy suffer from the breast cancer only is 0.3% ; patients who accept abdominal radiation therapy to treat wilms' tumor , the risk of suffering from breast cancer is just 4% .


Dr. Breslow said that if the patient's breast tissue received 20 or more gray radiation therapy, early screening should be added to the childhood Cancer Survivors , which will be very critical. for revealing the risk of suffering from breast cancer as well as early treatment for these individuals . The researchers also pointed that Wilms' tumor patients with high risk need to check x-ray and the breast MRI . This new research provides a new method to treat breast cancer . And in the future researchers also need to overcome many obstacles to achieve greater success .

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